Download Long Shot: Vaccines for National Defense by Kendall Hoyt PDF

By Kendall Hoyt

At the flip of the twenty-first century, the us contended with a state-run organic battle software, bioterrorism, and a scourge. jointly, those threats spurred large-scale govt call for for brand new vaccines, yet few have materialized. a brand new anthrax vaccine has been a concern because the first Gulf conflict, yet 20 years and a thousand million funds later, the U.S. nonetheless doesn't have one. This failure is startling.

Historically, the us has excelled at responding to nationwide healthiness emergencies. global conflict II period courses built ten new or enhanced vaccines, usually in time to satisfy the pursuits of specific army missions. Probing the background of vaccine improvement for elements that foster well timed innovation, Kendall Hoyt stumbled on that vaccine innovation has been falling, no longer emerging, for the reason that international struggle II. This discovering is at odds with winning theories of market-based innovation and means that a set of nonmarket elements drove mid-century innovation. mockingly, many late-twentieth-century advancements which were celebrated as a boon for innovation—the delivery of a biotechnology and the increase of specialization and outsourcing—undercut the collaborative networks and study practices that drove winning vaccine initiatives within the past.

Hoyt’s well timed research teaches very important classes for our efforts to rebuild twenty-first-century biodefense functions, specially whilst the monetary payback for a specific vaccine is low, however the social returns are high.

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Extra info for Long Shot: Vaccines for National Defense

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1). Each regulatory body maintained an accurate record of current vaccines, but did not maintain records for companies that left the industry or for licenses that had been revoked. Each time regulatory responsibility changed hands, original approval dates were either lost or reentered with a more recent date, creating the false impression that there was a spate of innovation with each transition. Compounding this error, in the 1970s the FDA began to issue licenses for vaccines that were new in name only or for license transfers between companies.

Economic disincentives exist even for vaccines with viable markets. One such disincentive is inherent to the nature of vaccines themselves; products that offer long-term immunity after a minimal dose confound most profit-making strategies, since pharmaceutical companies prefer high-volume repeat sales. Some vaccines, used effectively, can eliminate their own market by eradicating the disease they prevent, as was the case with smallpox. Consumer behavior further weakens vaccine markets. People are more willing to pay to treat acute and existing conditions than they are to prevent an uncertain condition that might arise in the future.

B. Collins, president of National Drug, acknowledged that net earnings were falling despite record sales. It appears that many companies maintained vaccine divisions during this period, not entirely for economic reasons, but partly out of a sense of public and patriotic duty. ”41 In many respects, the long-term economic outlook for vaccines improved dramatically toward the end of the twentieth century. By the early 1980s, profits began to improve. Don Metzgar, a vaccine research scientist at Aventis Pasteur (formerly Connaught) during this period, observed, “Ironically, Connaught began to make more money on vaccines when litigation became so prevalent.

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