By Ivan Curtis
This publication found in novel, precise, yet hugely comparable facets of the intracellular mechanisms required for the formation of a sensible neurite, which come with cytoskeletal association, membrane site visitors, and sign transduction. Its target is to offer this subject to the final readership of neurobiologists and molecular and mobile biologists to extra stimulate the curiosity into this interesting part of neurobiology.
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Additional resources for Intracellular Mechanisms for Neuritogenesis
AC activity is localized to the peripheral leading edge of advancing and turning growth cones. Ratio imaging of relative AC activity (determined by ratio imaging as described in legend of Figure 3) in a hippocampal neuronal growth cone that does not experience contact with a guidance cue (top series) and a growth cone that has contacted and is turning away from an aggrecan stripe (red fluorescence barrier in lower right panel). Left panels are phase contrast images and center panels are the ratio images with overlays on the right.
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As a result, actin-binding proteins, which largely determine the constitution and dynamics of actin-dependent systems, are important targets of growth cone regulation (Letourneau, 1996). , 2004; Meberg, 2000; Meyer and Feldman, 2002; Sarmiere and Bamburg, 2004). This chapter reviews over two decades of studies that have defined a niche for the ADF/cofilin (AC) family proteins in regulating actin dynamics that are important to growth cone formation, borrowing heavily from work performed in nonneuronal systems.