Download Intracellular Mechanisms for Neuritogenesis by Ivan Curtis PDF

By Ivan Curtis

This publication found in novel, precise, yet hugely comparable facets of the intracellular mechanisms required for the formation of a sensible neurite, which come with cytoskeletal association, membrane site visitors, and sign transduction. Its target is to offer this subject to the final readership of neurobiologists and molecular and mobile biologists to extra stimulate the curiosity into this interesting part of neurobiology.

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AC activity is localized to the peripheral leading edge of advancing and turning growth cones. Ratio imaging of relative AC activity (determined by ratio imaging as described in legend of Figure 3) in a hippocampal neuronal growth cone that does not experience contact with a guidance cue (top series) and a growth cone that has contacted and is turning away from an aggrecan stripe (red fluorescence barrier in lower right panel). Left panels are phase contrast images and center panels are the ratio images with overlays on the right.

1999, Organization of point contacts in neuronal growth cones, J. Neurosci. Res. 55: 458–471. , 2004, Control of axonal branching and synapse formation by focal adhesion kinase, Nat. Neurosci. 7: 1059–1069. , 2003, Cell migration: Integrating signals from front to back, Science 302: 1704–1709. , 2005, Src-dependent tyrosine phosphorylation at the tips of growth cone filopodia promotes extension, J. Neurosci. 25: 7669–7681. , 1986, Distribution of laminin in the developing peripheral nervous system of the chick, Dev.

As a result, actin-binding proteins, which largely determine the constitution and dynamics of actin-dependent systems, are important targets of growth cone regulation (Letourneau, 1996). , 2004; Meberg, 2000; Meyer and Feldman, 2002; Sarmiere and Bamburg, 2004). This chapter reviews over two decades of studies that have defined a niche for the ADF/cofilin (AC) family proteins in regulating actin dynamics that are important to growth cone formation, borrowing heavily from work performed in nonneuronal systems.

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