By Akete Lex Adjei, Pramod K. Gupta
This exhaustive reference-the first booklet of its type to explain intimately the performance of the human breathing tract and its influence on either neighborhood and systemic supply of biotherapeutic and macromolecular drug systems-offers finished analyses of peptide and protein drug supply throughout the lung. Summarizes over a hundred thirty patents granted all over the world on replacement platforms for pulmonary supply of healing drugs-especially peptides and proteins! interpreting macromolecular drug supply as a good, patient-friendly, and budget friendly approach to therapy, Inhalation supply of healing Peptides and Proteins discusses ·airway body structure and biomechanics ·the pharmaceutical issues linked to the breathing tract as a attainable port of drug access to the physique ·key peptide medicines below improvement and in use to regard neighborhood lung disorder, together with cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases ·the systemic supply of peptide and protein medicinal drugs utilizing fine-particle know-how ·gene remedy applying gene supply throughout the airlines ·new advancements in pulmonary supply applied sciences emphasizing inhaled peptide and protein medicines ·guidelines for the profitable creation of peptide inhalation aerosol items into undefined ·and even more!
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Additional resources for Inhalation delivery of therapeutic peptides and proteins
In Vivo Studies 754 IV. Human Studies 757 V. Stability Studies 762 VI. Conclusions 767 References 767 Page xxxii 26. Clinical Development of Inhaled Peptides and Proteins Akwete Lex Adjei 771 I. Introduction 771 II. Structural Issues and Bulk Drug Stability 773 III. Formulation Development and Drug Dosimetry 777 IV. Inhalation Toxicology and Immunogenicity 795 V. Pharmacokinetics and Pharmacodynamics 797 VI. Conclusions 803 References 804 Part Eight Key WorldWide Patents in Pulmonary Drug Delivery Pramod K.
Macklem and Solbert Permutt 13. Evolution of Respiratory Processes: A Comparative Approach, edited by Stephen C. Wood and Claude Lenfant 14. Pulmonary Vascular Diseases, edited by Kenneth M. Moser 15. Physiology and Pharmacology of the Airways, edited by Jay A. Nadel 16. Diagnostic Techniques in Pulmonary Disease (in two parts), edited by Marvin A. Sackner 17. Regulation of Breathing (in two parts), edited by Thomas F. Hornbein 18. Occupational Lung Diseases: Research Approaches and Methods, edited by Hans Weil and Margaret Turner-Warwick 19.
Chronic Effects 306 IX. IFN Antibodies 307 X. Inhalational IFN: Preclinical and Clinical Data 307 XI. Conclusion 310 References 311 10. Alpha-1 Antitrypsin Richard C. Hubbard 315 I. Introduction 315 II. Protease-Antiprotease Balance in the Lower Respiratory Tract 315 III. In Vitro Evaluation of Alpha-1 Antitrypsin 317 IV. Conceptual Basis of A1AT Augmentation Therapy 318 V. Aerosol Augmentation Therapy 320 VI. Administration of A1AT to Patients with A1AT Deficiency 323 VII. Aerosolized A1AT in Cystic Fibrosis 327 Page xxvii VIII.