Download Inhalation delivery of therapeutic peptides and proteins by Akete Lex Adjei, Pramod K. Gupta PDF

By Akete Lex Adjei, Pramod K. Gupta

This exhaustive reference-the first booklet of its type to explain intimately the performance of the human breathing tract and its influence on either neighborhood and systemic supply of biotherapeutic and macromolecular drug systems-offers finished analyses of peptide and protein drug supply throughout the lung. Summarizes over a hundred thirty patents granted all over the world on replacement platforms for pulmonary supply of healing drugs-especially peptides and proteins! interpreting macromolecular drug supply as a good, patient-friendly, and budget friendly approach to therapy, Inhalation supply of healing Peptides and Proteins discusses ·airway body structure and biomechanics ·the pharmaceutical issues linked to the breathing tract as a attainable port of drug access to the physique ·key peptide medicines below improvement and in use to regard neighborhood lung disorder, together with cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases ·the systemic supply of peptide and protein medicinal drugs utilizing fine-particle know-how ·gene remedy applying gene supply throughout the airlines ·new advancements in pulmonary supply applied sciences emphasizing inhaled peptide and protein medicines ·guidelines for the profitable creation of peptide inhalation aerosol items into undefined ·and even more!

Show description

Read or Download Inhalation delivery of therapeutic peptides and proteins PDF

Best nonfiction_4 books

Derivative Strategies for Managing Portfolio Risk

This lawsuits probes the possibilities for utilizing family and overseas fairness, fixed-income tools, and foreign money derivatives--including innovations, futures, forwards, and swaps--in the portfolio administration strategy. complaints of the AIMR seminar held April 13-14, 1993 in Marina Del Rey, California.

Managing Infections in Patients With Hematological Malignancies

Dealing with infections that complicate care of neutropenic sufferers with leukemia and hematopoietic stem phone recipients has develop into a different forte. In coping with Infections in sufferers with Hematological Malignancies, the authors and editor draw on their large services whereas offering a roadmap for hematologists to successfully deal with the complicated infections inside of their sufferers.

RAF Mustang and Thunderbolt Aces (Aircraft of the Aces 93)

The P-51 Mustang and P-47 Thunderbolt have been the best American warring parties of worldwide conflict 2, and either observed provider with the RAF in tremendous numbers. The RAF all started flying the Mustang in 1944, utilizing it to fly bomber escort missions, and deploying to help the floor campaigns in Italy and the Balkans. It was once additionally flown through a couple of Polish devices within the RAF.

Pilgrims to the wild: Everett Ruess, Henry David Thoreau, John Muir, Clarence King, Mary Austin

Pilgrims to the Wild is a survey of yank writers who've spoke back to their encounters with the wildlife. Ranging in its therapy from Thoreau’s vital yet overlooked essay, 'Walking,' to the exuberant letters of the younger artist Everett Ruess (who disappeared within the Escalante canyonlands), this can be a commonly established exploration that brings to undergo jap and Western classical philosophy, in addition to modern severe idea, on a particular culture of yank Writing—those works thinking about the human dating to the nonhuman international.

Additional resources for Inhalation delivery of therapeutic peptides and proteins

Sample text

In Vivo Studies 754 IV. Human Studies 757 V. Stability Studies 762 VI. Conclusions 767 References 767 Page xxxii 26. Clinical Development of Inhaled Peptides and Proteins Akwete Lex Adjei 771 I. Introduction 771 II. Structural Issues and Bulk Drug Stability 773 III. Formulation Development and Drug Dosimetry 777 IV. Inhalation Toxicology and Immunogenicity 795 V. Pharmacokinetics and Pharmacodynamics 797 VI. Conclusions 803 References 804 Part Eight Key WorldWide Patents in Pulmonary Drug Delivery Pramod K.

Macklem and Solbert Permutt 13. Evolution of Respiratory Processes: A Comparative Approach, edited by Stephen C. Wood and Claude Lenfant 14. Pulmonary Vascular Diseases, edited by Kenneth M. Moser 15. Physiology and Pharmacology of the Airways, edited by Jay A. Nadel 16. Diagnostic Techniques in Pulmonary Disease (in two parts), edited by Marvin A. Sackner 17. Regulation of Breathing (in two parts), edited by Thomas F. Hornbein 18. Occupational Lung Diseases: Research Approaches and Methods, edited by Hans Weil and Margaret Turner-Warwick 19.

Chronic Effects 306 IX. IFN Antibodies 307 X. Inhalational IFN: Preclinical and Clinical Data 307 XI. Conclusion 310 References 311 10. Alpha-1 Antitrypsin Richard C. Hubbard 315 I. Introduction 315 II. Protease-Antiprotease Balance in the Lower Respiratory Tract 315 III. In Vitro Evaluation of Alpha-1 Antitrypsin 317 IV. Conceptual Basis of A1AT Augmentation Therapy 318 V. Aerosol Augmentation Therapy 320 VI. Administration of A1AT to Patients with A1AT Deficiency 323 VII. Aerosolized A1AT in Cystic Fibrosis 327 Page xxvii VIII.

Download PDF sample

Rated 4.10 of 5 – based on 17 votes