By Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee
This 8th and ultimate file of the Immunization protection assessment Committee examines the speculation that vaccines, particularly the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally linked to autism. The committee reviewed the extant released and unpublished epidemiological reports concerning causality and reports of capability biologic mechanisms in which those immunizations could reason autism. Immunization defense evaluation: Vaccines and Autism reveals that the physique of epidemiological facts favors rejection of a causal dating among thimerosal-containing vaccines and autism. The ebook extra reveals that power organic mechanisms for vaccine-induced autism which have been generated thus far are just theoretical. It recommends a public well-being reaction that totally helps an array of vaccine defense actions and recommends that on hand investment for autism learn be channeled to the main promising parts. The booklet makes extra strategies relating to surveillance and epidemiological study, scientific stories, and communique concerning those vaccine safeguard concerns.
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Additional info for Immunization Safety Review: Vaccines and Autism
24 25 VACCINES AND AUTISM BOX 1 Previous Reports of the Immunization Safety Review Committee Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism (IOM, 2001a) Immunization Safety Review: Thimerosal-Containing Vaccines and Neurodevelopmental Disorders (IOM, 2001b) Immunization Safety Review: Multiple Immunizations and Immune Dysfunction (IOM, 2002b) Immunization Safety Review: Hepatitis B Vaccine and Demyelinating Neurological Disorders (IOM, 2002a) Immunization Safety Review: SV40 Contamination of Polio Vaccine and Cancer (IOM, 2002c) Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy (IOM, 2003) Immunization Safety Review: Influenza Vaccines and Neurological Complications (IOM, 2004) materials reviewed by the committee, including many items not cited in this report, can be found on the project’s website.
Studies conducted during the same period and those conducted more recently (Gillberg and Wing, 1999). , 2001). These rates are higher than those reported in previously published studies although, as noted above, there is significant controversy about the actual rate of ASD in the United States. The authors note several factors that may have contributed to the high rates of autism and ASD including: the intensity of case-finding methods, the small size of the target population, the heightened awareness of the issue in the community, and the use of the Autism Diagnostic Observation Schedule-G (ADOS-G) diagnostic tool, which is a sensitive tool that may have led to the inclusion of children with more subtle signs of ASD.
The Immunization Safety Review Committee is responsible for examining a broad variety of immunization safety concerns. Committee members have expertise in pediatrics, neurology, immunology, internal medicine, infectious diseases, genetics, epidemiology, biostatistics, risk perception and communication, decision analysis, public health, nursing, and ethics. While all of the committee members share the view that immunization is generally beneficial, none of them has a vested interest in the specific immunization safety issues that come before the group.