By Wallace B. Mendelson, J. Christian Gillin, Richard Jed Wyatt (auth.)
In this booklet we hint the improvement of a number of significant subject matters in sleep examine, from the 1st formal description of REM sleep within the early Fifties during the current. bankruptcy 1 offers these much less acquainted with this region with a standpoint at the many attainable how one can learn sleep. bankruptcy 2 describes intimately a massive perspective of this booklet: that observations of pharmacological interventions affecting the neurotrans mitters could relief within the figuring out of sleep rules. The stay der of the ebook is dedicated to endocrine structures on the topic of sleep (chap. three) and to the contribution of sleep study to the certainty of varied pathological states (chaps. 4-7). The parts of research open to those that desire to comprehend sleep are a lot broader than the conventional difficulties of insomnia and narcolepsy. Such issues as melancholy, schizophrenia, and alcoholism have lengthy been linked to disordered sleep. Our look for an figuring out of the latter phenomena may perhaps make clear the character of those conditions.
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Additional resources for Human Sleep and Its Disorders
Sample text
SEROTONIN TRICYCLICS --....... 5HT 5HT ~ II I- METHYSERGIDE FIGURE 2-1. Synthesis and degradation of serotonin. Hypothesized actions of drugs discussed in text are shown. A PHARMACOLOGIC APPROACH TO SLEEP STUDIES 23 5 ORMAlS 101, UTES REM SlEEP 140 1201 100 80 GOt ~ 350 R£M ACT WITY 300 250 · '"~200 ~ ISO 100 1 ,I I L -TRYPTOPHAN 75 0 1Q :z: .... ,I I I ~ :0' C> 5 10 IGHT 15 20 FIGURE 2-2 . 5 gm/24 hr of L-tryptophan on the REM sleep of five normal volunteers. (From Wyatt, 1972. ) the clinical EEG and drowsiness (but not euphoria) following parenteral administration.
S. S. S. S. S. S. 5. 5. S. 5. S. S. S. S. S. S. 5. S. S. S. S. S. S. S. S. S. S. S. S. S. l' l' l' l' No. S. S. S. 5. S. Total sleep TABLE 2-3. S. = not stated. • Formal tests for significance not reported. 66 LV. S. S. 3 mgl kg) i (pts. S. 5. S. S. S. S. S. (pts. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. 5. S. S. 40 CHAPTER TWO II NO PUlE T ~Ul[S 2 26 'l Ell SLEEP 400 100 I I I I I I I o L----4If-1- - - - ' - - ---'--+--'----IIINUTES I O~REII SLEtp I 160 : I I I I I I I ,I 80 60 40 20 FIGURE 2-9.
S. S. S. S. S. S. S. S. S. S. S. S. l' l' l' l' No. S. S. S. 5. S. Total sleep TABLE 2-3. S. = not stated. • Formal tests for significance not reported. 66 LV. S. S. 3 mgl kg) i (pts. S. 5. S. S. S. S. S. (pts. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. S. 5. S. S. 40 CHAPTER TWO II NO PUlE T ~Ul[S 2 26 'l Ell SLEEP 400 100 I I I I I I I o L----4If-1- - - - ' - - ---'--+--'----IIINUTES I O~REII SLEtp I 160 : I I I I I I I ,I 80 60 40 20 FIGURE 2-9. Sleep response during administration of L-DOPA in combination with the peripheral decarboxylase inhibitor MK485.