By Sheldon J. Segal (auth.), Sheldon J. Segal (eds.)
The look for a reversible male contraceptive has based upon the suppression of sperm construction or sperm motility. Gossypol, a common substance extracted from the cotton plant, seems to reason either one of those results. Its skill to minimize spermatogenesis in males is indisputable and has been validated in either huge reports in China and a smaller confirmatory learn in Brazil. those investiga tions have printed the impressive undeniable fact that with gossypol, it truly is attainable to split an impression at the testis' gamete-producing functionality from an influence on its hormone-producing functionality. therefore, it really is attainable to keep up basic testosterone degrees and libido whereas sperm counts (and motility) fall. due to this exact and critical motion, gossypol warrants the fullest attainable overview as a possible male contraceptive. Sheldon J. Segal vii ACKNOWLEDGMENT Lynn C. Landman performed an enormous position during this booklet by way of skillfully enhancing the manuscripts which have been submitted for inclusion during this quantity. Janet O'Connell further her efforts in enhancing, assembling texts and figures and dealing with ultimate info required for book. I thank those gifted colleagues for his or her necessary contributions.
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Extra resources for Gossypol: A Potential Contraceptive for Men
Animals of. Long Evans strain and 3 out of 15 animals of Fisher strain died within the first 3 days of treatment. 5 mg/kg/day for the 4th, 5th, and 6th weeks are presented in Fig. 2. There were no significant differences in the body weight gain of the animals treated with 15 mg/kg during the first 3 weeks of t r eatment as compared to that of the controls. 5mg/Kg 440 'ol. . , ~ 0 III 360 340 320 ,, ,, Z6 300 r 2 3 4 5 6 Weeks Fig. 2. 5 mg/kg/day for the 4th, 5th, and 6th weeks. Each datum point represents the mean ± SEM of the number of animals indicated in parentheses.
1). ASSESSMENT OF TOXICITY AND ANTIFERTILITY EFFICACY OF GOSSYPOL IN MALE RATS Chin-Chuan Chang and Sheldon J. A. A. INTRODUCTION The discovery by Chinese scientists of gossypol as an antifertility agent for men aroused a great deal of interest around the world in assessing its fertility regulating action in a variety of laboratory animals. In addition to its widely reported toxic effects in animals, it had been reported that when given at high doses, gossypol also caused death in some animal species characterized by generalized edema, hemorrhages, and necrosis of the liver [1, 2].
Dym, Effects of gossypol on the reproductive system of male rats, J. , 2:190 (1981). A. P. , 8:233 (1982). L. F. Zhou, C. C. Chen, N. G. Wang, and H. P. Lei, Observations on long-term administration of gossypol acetic acid to rats, Nat. Med. , 60:343 (1980). C. C. Chang, Z. P. Gu, and Y. Y. Tsong, Studies on gossypol. I. Toxicity, antifertility, and endocrine analyses in male rats, Int. J. , 27:213 (1982). National Coordinating Group on Male Infertility Agents, 1978, op. cit. (see Ref. 7). S. P.