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By Choh Hao Li

Hormonal Proteins and Peptides, quantity XI: Gonadotropic Hormones offers with gonad stimulating hormones that reason precocious sexual maturity.

This ebook starts through reviewing the connection of the chemical constitution to the organic job of gonadotropins and chorionic hormones, through a short presentation at the in vitro bioassay tools. A accomplished dialogue on a few points of the molecular mechanism of gonadotropin motion can also be supplied. This ebook concludes with an research of the immunobiology of gonadotropins.

This ebook is meant for endocirnologists, yet can also be invaluable for scientific practitioners and researchers concerned about gonadotropic hormones.

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Further, in the latter instance, the recombined hormone retains some activity (Faith and Pierce, 1975). These data are similar to the role of amino groups discussed in Section V,A and emphasize the importance of correct charge retention more par­ ticularly in the a subunit for effective recombination. It is remarkable that elimination of either positively or negatively charged groups and conver­ sion to neutral ones on the β subunit of LH (bovine or ovine) has no significant effect on recombination with the native a subunit.

34 M. R. SAIRAM VI. Subunit and Receptor Interaction Site Mapping The three glycoprotein hormones are similar hormones recognizing dif­ ferent receptors and inducing different responses. It is likely that their subunit interactions are very similar, if not identical, but that their recep­ tor binding sites are probably different, accounting for their highly specific effects. From the rather extensive series of modifications on LH, hCG, and TSH (as discussed in the previous sections), the nature of the sites in the domain of subunit interaction and receptor binding is being defined.

1974a) Tetrin-Clary et al. (1980) Sairam (1976) Mori et al. (1978) Alkylation Cheng (1976a,b) Goverman and Pierce (1981) Carbodimide-ester/crosslinking Combarnous and Hennen (1974) Faith and Pierce (1975) Parsons and Pierce (1979) Weare and Reichert (1979) Dye photooxidation Aggarwal and Papkoff (1979) Partial reduction/alkylation/ Reduction reoxidation Partial reduction/alkylation Giudice and Pierce (1979) Giudice and Pierce (1976) Mori et al. (1977) Nitration Human lutropin Amino and guanidino Ovine lutropin hCG Methionine Bovine lutropin Acidic groups Bovine lutropin groups Bovine lutropin Histidine Ovine lutropin —5—1S—bridges Bovine lutropin a hCG Photocoupling Ovine lutropin hCG Burleigh et al.

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