By Gwilherm Evano, Nicolas Blanchard
Providing finished perception into using copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides an entire up to date choice of the to be had reactions and catalytic platforms for the formation of carbon-heteroatom and carbon-carbon bonds. This crucial reference covers a huge scope of copper-mediated reactions, their diversifications, key advances, advancements, and an array of educational and business functions that experience revolutionized the sphere of natural synthesis. The textual content additionally discusses the mechanism of those alterations, using copper as good value replacement to palladium, in addition to lately built equipment for accomplishing copper-mediated reactions with supported catalysts.
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Extra info for Copper-Mediated Cross-Coupling Reactions
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19, Eq. 20. 20, Eq. 20, Eq. 20, Eq. 20, Eq. [49b] As evidenced with all results overviewed in this section, a wide range of N-nucleophiles can be efficiently arylated under relatively mild conditions and with high efficiency. The introduction of chelating ligands for copper also enabled the development of efficient procedures for the arylation of another most useful class of N-nucleophiles: conjugated N-heterocycles. Advances in this area will be overviewed in the next section of this chapter. 24 ARYLATION OF N-NUCLEOPHILES WITH ARYL HALIDES CuI (1–5 mol %) I R HN + N N (10–20 mol %) Cs2CO3 Boc DMF, 80°C NH2 Boc N R NH2 14 examples 43–97% yield (Eq.