By J. Victor Small, Klemens Rottner (auth.), Marie-France Carlier (eds.)
This publication offers the mobile, molecular and actual facets of strength and circulation by way of the self-assembly of actin, probably the most considerable proteins present in cells, into cytoskeletal filaments. « Actin-based motile techniques » are liable for a wide number of motile actions comparable to chemotactic locomotion, embryonic and metastatic mobilephone migration, wound therapeutic, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic actions, in addition to morphogenetic tactics together with, axis patterning in early embryos, axonal development in mind improvement, and the immune reaction and synaptic plasticity tactics on the starting place of studying and reminiscence. The e-book describes how the lately undertaken multidisciplinary and multiscale ways have explored the molecular and actual mechanisms on the foundation of strength and circulation produced by way of actin self-assembly. the selected issues exhibit how advances were made within the box of cellphone motility a result of growth in dwell phone imaging, gentle microscopy, enhanced answer within the constitution of enormous protein assemblies, the biochemical research and mathematical modeling of actin meeting dynamics and the improvement of nanotechnologies permitting us to degree forces within the variety of pico- to nano-newtons produced by way of actin assemblies.
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Extra info for Actin-based Motility: Cellular, Molecular and Physical Aspects
A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. EMBO J. 16:5433–44. , and A. Hall. 1995. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 81:53–62. , N. Tomasevic, A. W. Pierce, Z. D. McCormick, J. Hartman, R. D. Pollard. 2009. Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
8 Contribution of ruffling to actin cytoskeleton assembly. g. a neutrophil). Ruffles, including lamellipodia and filopodia fold back into the cell and contribute actin filament seeds for the formation of antiparallel assemblies with myosin that interconnect throughout the cell body. The contractile bundle around the periphery of the trailing part of the cell is formed via prior ruffling activity at those locations. Actin filaments are in green, myosin filaments in blue (Fig. 8). , 2008), it is not directly dependent on myosin II.
Mol Cell. 24:13–23. B. Gertler. 2009. Ena/VASP: Towards resolving a pointed controversy at the barbed end. J Cell Sci. 122:1947–53. M. Svitkina, M. A. J. A. V. Y. A. G. B. Gertler. 2002. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell. 109:509–21. , S. Lommel, A. E. Stradal, N. Scaplehorn, M. Way, J. Wehland, and K. Rottner. 2002. Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.